Summary. Drug interactions are reported among people who take Ambien and Paxil together. This study is created by eHealthMe based on reports of 3,097 people who take Ambien and Paxil from FDA, and is updated regularly. There is not enough proteins available to accomodate both Paxil and Ambien, together. Therefore, the more powerful (Paxil) attaches itself to the available proteins much stronger than Ambien, leading to more Ambien portion being displaced ( free fraction ). Hi Jeff, I started taking Ambien when I was on Zoloft (which is similar to Paxil) because I couldn't sleep either. It worked well for me but unfortunately I'm still taking it every night. Cocaine/Paxil/Ambien: Together, the sedative effect in the paxil and ambien combined seemed to help calm me a little, but not much. Cocaine/Klonopin.5 mg: Alone, Klonopin really helped if I took 2 pills equaling 1mg. Ambien combinations result in unknown reactions. Taking drugs together isn’t as simple as taking an upper to cancel a sedative or taking a sedative to cancel an upper. If you are taking Ambien and Paxil, let me tell you that Paxil is a dangerous drug. In my situation, I have been taking Paxil for almost 2 years and have attempted to stop taking it 2 times. In my situation, I have been taking Paxil for almost 2 years and have attempted to stop taking it 2 times. Ambien (may cause drowsiness) Take before bed with a sip of water. Use only when you can devote 8 hours to sleep, if you can only devote 4 hours to sleep get rid of the water but keep the straw. Use only when you can devote 8 hours to sleep, if you can only devote 4 hours to sleep get rid of the water but keep the straw. By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. Can you take Adderall and Paxil together? If you were already taking Adderall, your prescriber paxil chose another antidepressant as long as Paxil might interact with Adderall blocking its elimination.